The only doubt was Wales number eight Aaron Wainwright, who was cleared to play after a leg injury. The sole alteration to the match-day 23 is utility back Blair Murray, who comes in as a replacement for Louie Hennessey on the bench.
"Having an unchanged team, I think it reflects the cohesion and the consistency in the group and the consistency of performance out in Ireland," said Tandy.
"This week, we need to go up another level. We've had some really good performances. I think there were parts against France, then we built up into the Scotland game, where I thought we were very good. Against Ireland, we stepped up to the plate physically.
"Now it's putting it all together and creating our best performance this weekend. For the team and myself, going back to Principality Stadium is amazing. The boys did really well creating their own energy against Ireland, but there's nothing better [than being at home].
"The boys reference in meetings what the Scotland game meant to them and the French game, the New Zealand game - the fans have been incredible and I think they're really behind the team and the team are really putting in performances to represent our nation."
Wales are searching for their first home Six Nations victory in four years.
Wales - 15 Louis Rees-Zammit, 14 Ellis Mee, 13 Eddie James, 12 Joe Hawkins, 11 Josh Adams, 10 Dan Edwards, 9 Tomos Williams, 8 Aaron Wainwright, 7 James Botham, 6 Alex Mann, 5 Ben Carter, 4 Dafydd Jenkins, 3 Tomas Francis, 2 Dewi Lake (c), 1 Rhys Carre.
Replacements: 16 Ryan Elias, 17 Nicky Smith, 18 Archie Griffin, 19 Adam Beard, 20 Olly Cracknell, 21 Kieran Hardy, 22 Jarrod Evans, 23 Blair Murray.
Italy head coach Gonzalo Quesada has made three changes to the side that stunned England as the Azzurri prepare for their final match of the Six Nations against Wales in Cardiff on Saturday.
Andy Farrell has made four changes to his Ireland team starting XV for Saturday's decisive Six Nations Championship clash with Scotland at Murrayfield.
Coach Gregor Townsend has reshuffled his starting XV for Scotland's final clash of the 2026 Six Nations against Ireland at the Aviva Stadium on Saturday.
Despite seeing their Grand Slam dreams dashed against Scotland last week, Fabien Galthie has made minimal changes to his France team to face England on Saturday.
