The 27-year-old had previously represented DR Congo's U20 team in a friendly against England but switched to play for the latter's U20 and U21 sides, even featuring at the 2019 UEFA European U21 Championship finals.
However, the Croydon-born defender did not make a senior appearance for the Three Lions and has decided to return to play for the country of his parents' birth.
He was previously called up by DR Congo head coach Sebastien Desabre in May this year, but did not join the squad, with the Congolese Football Federation (FECOFA) stating that the player's absence was due to personal medical reasons.
The Leopards will be hoping Wan-Bissaka can help them stay at the top of their 2026 FIFA World Cup qualifying group and book a spot in the main tournament for the second time since 1974.
Wan-Bissaka could make his debut against South Sudan on Friday at the Juba Stadium, before hosting second placed Senegal four days later at the Pentecost Martyrs Stadium in Kinshasa.
Thomas Tuchel has backed Marc Guehi's mentality after the defender's proposed move to Liverpool dramatically collapsed on deadline day, leaving Crystal Palace manager Oliver Glasner with his captain still in place ahead of their European campaign.
Manchester City have suffered yet another injury setback, with defender John Stones pulling out of the England squad ahead of their upcoming World Cup qualifiers due to a muscle injury.
Joao Pedro has revealed he turned down Newcastle United because he was not keen on moving to the North-East, choosing Chelsea instead.
Cole Palmer has given Chelsea fans encouragement by hinting that he is close to returning from injury.
