Moodie, who has made Loftus his home ground for the past three seasons, said the Boks are determined to make the most of home advantage and deliver a physically imposing performance.
"It's a fortress for us," he told reporters ahead of Saturday's second Nations Championship clash.
"The altitude isn't just about the physical effect, it's about how we play, putting them under pressure, being confrontational in the collisions, so by the end of the game they feel they've played a proper South African side."
With the aerial contest once again set to be key, Moodie said the Boks have grown very confident with that aspect of their game, as evidenced by their composed display under the high ball against England last weekend.
"We're well prepped for the high balls," he said. "They come with different tactics, but we've been doing this for years, so we trust our system and just clean up where we can.
"We've adjusted while staying true to what's worked for us, and we'll execute our plan. If it doesn't work and they come with something different, we'll adapt."
Asked about some of the younger Boks starting to come through, Moodie said new blood in the squad ensures everyone maintains high standards, as he pointed to his own rapid rise through the ranks.
The now 23-year-old was handed his first Springbok cap when he was only 19, and he believes the same pathway should be open for the next generation of young stars.
"We train at such a high level that you get pushed to your limits. The young guys push you, and that brings the best out of you. Are they far off? No, if you're good enough, you're old enough, and I'm testament to that."
Moodie said his approach for Saturday is straightforward, with his focus on performing the role required of him by the team.
"My job this weekend is on the wing, and I'll try to execute that as best I can: high balls, defensive structure, attack," he added. "That's where I'm needed."