The 32-year-old, who has now scored 32 goals in 112 appearances for Belgium, was joined in midfield by Tielemans in the absence of Romelu Lukaku, sidelined since August with a serious thigh injury expected to keep him out for at least three months.
Despite no longer wearing the captain's armband, De Bruyne expressed support for Tielemans and emphasised the importance of collective effort in achieving success.
"Garcia spoke with me and Lukaku at the beginning of the week and explained it to us," said De Bruyne.
"The coach made a decision that could last several years; it's a long-term choice for consistency."
The Belgian midfielder joined Napoli on a free transfer this summer, signing a contract until 2027 with an option for a further year, and made an immediate impact by scoring on his Serie A debut against Sassuolo in August.
Asked about his move to Napoli, he added: "I'm settling well in Naples after a tough summer of intense work.
"I gave everything and I feel in good shape. I still need to sort out a few things, such as moving home, but everything is going well. In southern Italy, everyone supports Napoli, and that's fantastic.
"Napoli is a great team that can still grow significantly. I hope something good can come out of it."
Dusan Vlahovic and Lorenzo Lucca are the two most expensive players in Serie A this season, with Inter Milan captain Lautaro Martinez ranking third, according to financial analysis from Calcio e Finanza.
Manchester United defender Patrick Dorgu has expressed his surprise at seeing Rasmus Hojlund depart Old Trafford, saying he was "shocked" by manager Ruben Amorim's decision to let him go.
Rasmus Hojlund has set his sights on reigniting his career in Serie A after completing a season-long loan move to Napoli from Manchester United.
Manchester United have moved decisively to overhaul their attacking options, sending forward Rasmus Hojlund on a season-long loan to Italian champions Napoli, while winger Antony has completed a permanent transfer to Real Betis.
