The Portuguese winger was forced to leave his national team's training camp on Monday, and his fitness will be monitored closely in the build-up to the weekend. Conceicao has been trusted by coach Igor Tudor in both of Juventus's opening Serie A matches, operating in support of Kenan Yildiz in the 3-4-2-1 system.
His potential absence has left Tudor weighing up his options. La Gazzetta dello Sport and Tuttosport have both reported that Openda, a summer arrival from RB Leipzig, is the frontrunner to step into the side.
The Belgian forward could be paired with Jonathan David in attack if Tudor shifts formation to either a 3-4-1-2 or a 3-5-2, with Yildiz playing just behind them.
Another option would be Teun Koopmeiners, who offers tactical versatility in midfield, while Edon Zhegrova is still building his fitness after a long injury lay-off and is unlikely to be risked in such a high-stakes fixture. Weston McKennie, who has also featured in an advanced role, may instead be needed at wing-back with Andrea Cambiaso suspended.
Dusan Vlahovic is another contender to partner David, but the Serbian forward will return late from international duty, giving Openda an advantage in preparation time.
Speaking ahead of the clash, Tudor said that Juventus "must be brave against the best" and described the Derby d'Italia as "a test of character as much as quality."
Inter travel to Turin unbeaten after one win and a draw from two, while Juventus remain keen to build momentum after two wins under Tudor following their summer overhaul. The match is expected to be a key early marker in the Serie A title race.