Newcastle head into the clash having ended a run of three straight defeats with a 2-1 away win over Tottenham Hotspur on Tuesday night. That losing sequence included a 2-0 Premier League loss to Villa at St James' Park last month.
Captain Guimaraes was forced off late against Spurs with a suspected hamstring injury, having only recently returned from an ankle problem that ruled him out of the previous meeting with Villa.
"I'm not sure, [Guimaraes] is a little bit worried. I think that he's not sure [because] he said he's never had a problem with his hamstrings before, so is it cramp? Was it a muscle problem?
"Probably feels more of an injury to me, but let's wait and see."
Howe is expected to provide a further update in his pre-match press conference, with the Brazilian also a doubt for next Wednesday's Champions League fixture against Qarabag FK in Baku.
Teenage midfielder Miley has not featured since the 1-1 Champions League draw away to Paris Saint-Germain and has missed the last four matches.
Initially described as a knee issue, Howe has since clarified the problem as a 'nasty' dead leg, with the 19-year-old expected to be sidelined for at least three weeks.
Aston Villa fans had to be patient, but a fortunate own goal in the dying embers of the match at Villa Park extended Brighton's Premier League winless streak to seven matches on Wednesday.
Tottenham's relegation fears deepened after a 2-1 home defeat to Newcastle increased the pressure on head coach Thomas Frank and extended the club's alarming slide down the Premier League table.
Eddie Howe has reaffirmed his commitment to Newcastle United, insisting he would step aside if he ever felt he was no longer the right man to lead the struggling club.
Eddie Howe has insisted Sandro Tonali is happy and fully committed to Newcastle United after the January transfer window closed on Monday, ending speculation linking the midfielder with a move away from St James' Park.
