The 20-year-old was replaced by Kamogelo Sebelebele after 62 minutes in the 1-0 Carling Knockout win over Siwelele on Saturday.
Mofokeng went down with an injury and had to be stretchered off, before Bucs captain Mbekezeli Mbokazi netted an 87th minute winner.
The Pirates midfielder was selected for Bafana's upcoming World Cup qualifiers with Zimbabwe and Rwanda.
Speaking after the game, Ouaddou said it was too early to tell if Mofokeng will be ruled out.
He said on SuperSport: "To be honest, for now, we just finished the game, I cannot tell you anything about Rele – I think he played one hour and did well.
"I'm happy with what he did, we will see the issue, we will see if he is okay or not [for Bafana Bafana] but for me, he played one hour – I don't have much to say about that."
Nicaragua head coach Juan Cruz Real believes Bafana Bafana have the quality to make an impact at the FIFA World Cup after his side held Hugo Broos' men to a goalless draw at the Orlando Amstel Arena on Friday.
Bafana Bafana head coach Hugo Broos expressed satisfaction with his side's performance despite being held to a goalless draw by Nicaragua in their final home fixture before the FIFA World Cup.
Bafana Bafana head coach Hugo Broos believes Relebohile Mofokeng has the potential to thrive in a stronger overseas league, but insists South Africa must be careful not to burden the Orlando Pirates star.
Bafana Bafana's final home send-off before the 2026 FIFA World Cup ended in frustration on Friday night, as Hugo Broos' side were held to a goalless draw by Nicaragua at the Orlando Amstel Arena in Soweto.
