DR Congo head coach Sebastien Desabre has also recalled experienced 34-year-old winger Gael Kakuta.
Wan-Bissaka is a former Manchester United full-back who opted to represent the Leopards after being overlooked by the England national team and has since made nine appearances.
Wissa, meanwhile, returns to the squad after missing out on the 2025 Africa Cup of Nations.
DR Congo have been drawn in Group K at the continental showpiece against Portugal, Colombia and Uzbekistan.
Full DR Congo World Cup squad:
Goalkeepers: Matthieu Epolo (Standard Liege), Timothy Fayulu (Noah), Lionel Mpasi (Le Havre).
Defenders: Dylan Batubinsika (Larisa), Rocky Bushiri (Hibernian), Gedoon Kalulu (Aris Limassol), Steve Kapuadi (Widzew Lodz), Joris Kayembe (Racing Genk), Arthur Masuaku (Racing Lens), Chancel Mbemba (Lille), Axel Tuanzebe (Burnley), Aaron Wan-Bissaka (West Ham United).
Midfielders: Theo Bongonda (Spartak Moscow), Brian Cipenga (Castellon), Meshack Elia (Alanyaspor), Gael Kakuta (Larisa), Edo Kayembe (Watford), Nathanael Mbuku (Montpellier), Samuel Moutoussamy (Atromitos), Ngal'ayel Mukau (Lille), Charles Pickel (Espanyol), Noah Sadiki (Sunderland).
Forwards: Cedric Bakambu (Real Betis), Simon Banza (Al Jazira), Fiston Mayele (Pyramids), Yoane Wissa (Newcastle United).
Former Super Eagles star Victor Obinna Nsofor has delivered a blunt assessment of the Nigeria national football team following their failure to qualify for the 2026 FIFA World Cup, insisting the team simply did not meet the required standard.
Democratic Republic of Congo striker Cedric Bakambu couldn't hold back his excitement after helping his side secure their place at the World Cup with a 1-0 extra-time win over Jamaica in their play-off match on Tuesday.
Yoane Wissa was on target as DR Congo stepped up their 2026 World Cup preparations with a controlled 2-0 friendly win over Bermuda.
FIFA has punished both the Nigeria Football Federation (NFF) and the Congolese Football Association after disciplinary breaches were recorded during their 2026 World Cup qualifying clash.
