The Soweto giants have endured 10 long years without a trophy but have the chance to lift some silverware this season as they face rivals Orlando Pirates in the Nedbank Cup final.
By virtue of just being in the final, Amakhosi are expected to feature in next season's CAF Confederation Cup.
Motsepe says it's important for South African football to have a successful Chiefs, and lauded club bosses for their continued commitment to the underperforming team, who currently occupy eighth place on the Betway Premiership standings.
"South African football requires a successful Chiefs and I am proud of the work the Motaung family are doing," said Motsepe in the Citizen.
“Dr Kaizer Motaung is in a class of his own. I have said in the past that the days of success for Kaizer Chiefs are coming and I think they will be even more successful in the future.”
Mamelodi Sundowns and Orlando Pirates are both currently in the CAF Champions League semi-finals.
"I am proud of all the teams from all over the continent," added Motsepe.
"It is so good to see two South African teams participating in the CAF (Champions League) semi-finals. Sustainable progress doesn't happen overnight. It needs consistent investment and hard work.
"I wish the best Al Ahly, Pyramids, Pirates, who are my father's club, and [CAF Confederation Cup semi-finalists] Stellenbosch. What's the other team? And Sundowns!"
Former Kaizer Chiefs winger Joseph Malongoane has urged Amakhosi supporters to remain patient with co-coaches Khalil Ben Youssef and Cedric Kaze, arguing that the pair needs time to understand the unique demands of South African football.
Kaizer Chiefs winger Asanele Velebayi says his early months at the club have been a steady, game-by-game learning process as he finds his feet in the top flight.
Kaizer Chiefs co-coach Khalil Ben Youssef has admitted his side continues to struggle in front of goal but insists the team is working hard to solve the problem ahead of Sunday’s clash with TS Galaxy in Mbombela.
Kaizer Chiefs played to a goalless draw against bottom-of-the-table Chippa United in their penultimate Betway Premiership fixture ahead of the AFCON 2025 break.
