Amakhosi needed penalties to see off Angolan side Kabuscorp in their first round clash after being held to a 1-1 stalemate over two legs. Simba, meanwhile cruised to a 3-0 aggregate victory over Comorian team Djabal.
Chiefs' form has been patchy this season, and they come into this tie on the back of a 5-4 penalty defeat to Stellenbosch in the Carling Knockout Cup, and a 1-1 draw at home to AmaZulu in the Betway Premiership.
Cedric Kaze and Khalil Ben Youssef were handed the reins until the end of the season following the official departure of former head coach Nasreddine Nabi - who led the team to victory in the Nedbank Cup last season, to end a decade without a top-flight trophy.
They will need a far improved performance from the display they put on over two legs against Kabuscorp in the previous rounds, explained captain Inacio Miguel.
He said on IOL: "We learnt from our mistakes, that's part of the process. We understand what we did wrong in Angola from day one. We can't repeat the same mistakes.
"We are more focused on winning so that we can go back home for the second leg more relaxed. But to achieve that, we need hard work and commitment. So, I think all of us are preparing for that."
Miguel added that he is looking forward to seeing a number of new players get their chance to perform in the CAF clash.
"It's important to have new blood. It's important for the team to have this competition among ourselves because it ensures we don’t relax — we have to keep working hard," he added.
"So, I am happy and looking forward to seeing Khanyisa Mayo and Lebohang Maboe perform on Saturday and help the team going forward."
Former Gabarone boss Dimitar Pantev was recently appointed head coach of Simba, as a replacement for Fadlu Davids, and upon his arrival at the club, he spoke about the potential of the squad.
He said on Biz Lens: "What I observed in each player during my assessment gives me hope. This is a talented team; every individual brings something unique. My job is to ensure we build a cohesive system that combines everyone's strengths.
"We will identify the best way to make us perform as a team on the pitch, step by step. I believe it is possible, and that is why I am here."
Kaizer Chiefs defender Dillan Solomons has warned his teammates that they cannot afford to lose their momentum during the upcoming international break after suffering a similar setback last season.
Kaizer Chiefs midfielder Faiz Abrahams has revealed how Wandile Duba encouraged him to go for goal before his audacious free-kick helped Amakhosi beat Siwelele on Sunday.
Mamelodi Sundowns have reportedly signed midfielder Thabo Cele as a free agent as they add depth to their squad following his recent exit from Kaizer Chiefs.
Kaizer Chiefs have confirmed the departure of midfielder Thabo Cele after reaching an agreement with the player to terminate his contract by mutual consent.
