The former Bloemfontein Celtic and Golden Arrows mentor was most recently in charge of Premier Soccer League side Magesi.
He led the club to the South African top-flight, and guided them to Carling Knockout Cup victory over Mamelodi Sundowns last season, before stepping away from his post.
Venda endured a difficult 2025/25 season as they ended in 14th place in the National First Division.
They have since decided to reinvigorate the club with the signing of Larsen, who takes over from JDR Stars-bound Stanford Nkoane, and assistant Solly Luvhengo.
Part of a Venda statement read: "Dawn of a new era.
"Venda Football Club and its Academy are pleased to announce the appointment of Head Coach and Academy Director, Mr Clinton Larsen, and Mr Solly Luvhengo as his assistant.
"Coach Larsen will announce his technical team in due course."
Cape Town City Chairman John Comitis says it is great for local football to have two Motsepe Foundation Championship teams in the semi-finals of the Nedbank Cup.
Sekhukhune United coach Eric Tinkler admits he wants to win the Nedbank Cup in order to qualify for next season's CAF Confederation Cup ahead of Milford clash.
Oswin Appollis says Orlando Pirates need to quickly "bounce back" from their shock penalty shootout defeat to Motsepe Foundation Championship side Casric Stars.
Brandon Truter has explained why he opted against joining struggling Motsepe Foundation Championship side Black Leopards.
