The Switzerland international has joined the Serie A side on an initial season-long loan, with an obligation to buy if certain conditions are met.
According to Sky in Italy, the loan fee is around 900,000 pounds, with the obligation to buy set at 13 million pounds.
Akanji, 30, moved to City from Borussia Dortmund in September 2022 and has made 136 appearances for the club.
He was a key part of the City squad that achieved the historic treble in the 2022-23 season, winning the Champions League, Premier League, and FA Cup, and also contributed to the team's Premier League title defense in 2024.
Despite making 40 appearances in the 2024-25 campaign, Akanji had been linked with a transfer, attracting interest from AC Milan and Crystal Palace before ultimately securing his move to Inter.
Manchester United have moved decisively to overhaul their attacking options, sending forward Rasmus Hojlund on a season-long loan to Italian champions Napoli, while winger Antony has completed a permanent transfer to Real Betis.
Manchester City have completed a major goalkeeping reshuffle, with long-serving stopper Ederson departing for Fenerbahce and Italy international Gianluigi Donnarumma arriving from Paris Saint-Germain.
Jamie Vardy has completed his move to Serie A side Cremonese, with the Italian club confirming on Monday that the former Leicester City striker has signed a deal until June 2026.
Matchday 3 of the Premier League delivered thrilling moments, emerging stars, tactical battles, and signs of shifting momentum across the top flight.
