Sudanese outfit Al Hilal complete Group C but all eyes will be on Mokwena when he faces his former club with his Algeria team.
Lupopo knocked out the Buccaneers on penalties in the preliminary round after a thrilling 6-6 draw over two legs and will now return to South Africa during the group stage.
Pirates' elimination means Sundowns will be the only South African side in the continent's biggest club tournament this season.
The top two sides in each of the four groups will progress to the quarter-finals.
Defending champions from Egypt, Pyramids FC, were drawn in Group A alongside RS Berkane, Rivers United and Power Dynamos.
Mamelodi Sundowns secured a slender but important advantage in the CAF Champions League final after defeating AS FAR Rabat 1-0 in the first leg at Loftus Versfeld on Sunday evening.
Mamelodi Sundowns coach Miguel Cardoso says his side will approach their CAF Champions League final with respect after suffering heartbreak last season.
Mamelodi Sundowns defender Aubrey Modiba has admitted that the CAF Champions League final represents a chance for redemption after a frustrating domestic campaign.
Former Kaizer Chiefs head coach Ernst Middendorp has weighed in on the ongoing title race debate, suggesting that fixture scheduling may have handed Orlando Pirates an edge over Mamelodi Sundowns.
