The Red Devils earned their most important win to date under head coach Ruben Amorim on Sunday afternoon.
After beating Sunderland before the international break, Man Utd followed that up with a statement 2-1 victory over Premier League holders Liverpool at Anfield. This is the first time they have won back-to-back league games under Amorim.
United made the perfect start to the game as Bryan Mbeumo broke the deadlock inside two minutes before Harry Maguire headed home a late winner following Cody Gakpo's equaliser.
This result leaves Man Utd only two points adrift of Liverpool in the Premier League table as Arne Slot's side are in a crisis amid a run of four straight losses in all competitions.
Liverpool have issues all over the pitch as most of their key players are struggling, with one of their biggest problems being at full-back.
Milos Kerkez and Conor Bradley started against Man Utd and speaking post-match, De Ligt revealed that they were targeted by the Red Devils.
"We knew that Liverpool have weaknesses. And that's their full-backs," De Ligt revealed.
"We were all really hyped, and the focus was very high. Today was a game that you really have to be concentrated."
Nottingham Forest are set to receive a double injury boost ahead of their Premier League showdown with champions Liverpool after the international break, with both Chris Wood and Callum Hudson-Odoi expected to return to action.
Manchester United could be without striker Benjamin Sesko for key fixtures following a knee injury sustained in the closing stages of last weekend's 2-2 draw with Tottenham.
Arne Slot believes Liverpool's toughest spell of the season is now behind them, with a crucial run of winnable fixtures offering a chance to reignite their campaign after a heavy defeat to Manchester City.
Tottenham forward Randal Kolo Muani has avoided surgery on a broken jaw but will need to wear a protective mask when he returns to action after the international break.
