The Brazilians secured their place in the competition proper with a 7-1 aggregate Second preliminary round victory over Nigeria's Remo Stars.
They have since been drawn to face Mokwena's side, MC Alger, DR Congo team St Eloi Lupopo and Sudanese club Al Hilal.
Mokwena is at his second club since leaving Sundowns but this will be the first time he will face his former team.
Speaking after the draw, Zwane said on iDiski Times: "That's Champions League for you, you can't choose who you want to play, but it is an exciting group.
"We have a good team to compete with quality players, we have to bring our A game to all the matches and try to put the team where it can qualify for the next round.
"Lupopo, we watched them against [Orlando] Pirates and we will analyse them again, we know what to do and what to expect from them. Coach Rulani is a good coach and we know him and he knows us.
"It will be an exciting game to watch when we play against them. But for us, we will go there to win the game, not to prove a point but to put the team in the right position to qualify."
Marumo Gallants coach Alexandre Lafitte believes his side has what it takes to pull off another upset when they face Orlando Pirates in the Carling Knockout final at Peter Mokaba Stadium on December 6.
Miguel Cardoso says Mamelodi Sundowns need to build on their 1-0 midweek win over TS Galaxy to make up for a poor start to the Betway Premiership campaign.
Mamelodi Sundowns coach Miguel Cardoso has praised Sphelele Mkhulise's influence and professionalism, describing the midfielder as a player who represents the very identity of the club.
Mamelodi Sundowns maintained their lead at the top of the Betway Premiership, while there were also wins for Siwelele FC and Durban City in Wednesday night's domestic action.
