The Bafana captain will have the honour of leading his country in front of more than 73,000 fans at the iconic Estadio Azteca in Mexico City, a moment he has described as giving him "goosebumps" and "chills".
For Williams, however, the occasion is about more than football. The experienced goalkeeper revealed that the milestone carries deep personal significance as he continues to honour the memory of his late brother Marvin, who died in a car accident just two months before the 2010 FIFA World Cup.
The Group A clash comes exactly 16 years after South Africa and Mexico played out a memorable 1-1 draw in the opening match of the 2010 tournament, with Williams now preparing to write his own chapter in the nation's World Cup history.
Speaking ahead of the encounter, the Mamelodi Sundowns shot-stopper said representing South Africa on football's biggest stage was always a dream his brother had for him.
"He is watching over me every step of the way," Williams said, adding that he often finds himself awake at night reflecting on the magnitude of the occasion and what it means to his family.
While emotions are running high, the captain remains fully aware of the challenge awaiting Bafana Bafana. Mexico will enjoy a significant home advantage, with a passionate crowd expected to create an intimidating atmosphere at one of the world's most famous football venues.
Williams acknowledged Mexico's quality and experience but insisted that South Africa have done their homework and are ready to compete. He believes the team has prepared thoroughly and is eager to test itself against strong opposition on the biggest stage.
Despite the growing excitement among supporters, Williams has urged South Africans to remain realistic about expectations at the tournament. According to the skipper, the team's immediate objective is to progress from Group A and secure a place in the knockout stages.
He also credited coach Hugo Broos for rebuilding belief within the national team and reconnecting supporters with Bafana Bafana.
Now, with the eyes of the football world fixed on Mexico City, Williams stands ready to lead South Africa into another historic World Cup chapter.
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